An association between periodontal disease and cancer has been established in recent\nstudies, but no common etiology has been identified in the hopes of reducing the global burden of\nthese non-communicable diseases. This perspective article hypothesizes that the determinant\nmediating the association of periodontal disease with cancer is dysregulated phosphate\nmetabolism. Phosphate, an essential dietary micronutrient, is dysregulated in chronic kidney\ndisease, and both cancer and periodontal disease are associated with chronic kidney disease.\nReviewed evidence includes the association between phosphate toxicity and cancer development,\nand the association between periodontal disease and chronic kidney disease-mineral and bone\ndisorder includes conditions such as ectopic calcification and bone resorption, which may be\nindirectly related to periodontal disease. Dental calculus in periodontal disease contains calcium\nphosphate crystals that are deposited from excess calcium and phosphate in saliva. Alveolar bone\nresorption may be linked systemically to release of parathyroid hormone in response to\nhypocalcemia induced by hyperphosphatemia. More research is needed to examine the role of\ndysregulated phosphate metabolism in periodontal disease.
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